凝血指数用于预测高血压妊娠障碍
Xuejun Kou1, Qirong Li2, Zhonggui Pan3
1Department of Cardiology, Shandong Provincial Third Hospital Jinan 250031, Shandong, China.
American journal of translational research
|March 17, 2025
概括
凝血指标如血小板计数,血栓时间和纤维素原预测妊娠高血压障碍 (HDP). 这些标志物可以帮助评估HDP的严重程度,并指导临床管理,以改善母亲和婴儿的结果.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 围产儿医学 围产儿医学
背景情况:
- 妊娠中高血压疾病 (HDP) 对母亲和胎儿的健康构成重大风险.
- 早期发现和监测HDP对于改善结果至关重要.
- 凝血功能在HDP的病理生理学中起作用.
研究的目的:
- 调查妊娠中期到晚期的凝血功能指标与HDP的发展/严重程度之间的相关性.
- 评估这些指标对HDP的预测值.
- 为早期HDP检测和管理提供信息的战略.
主要方法:
- 从2020年10月到2023年10月,对300名孕妇 (182名HDP,118名对照) 的回顾性分析.
- 收集临床数据,包括年龄,妊娠年龄,平价.
- 通过血液检查评估凝血功能指标.
主要成果:
- 血小板计数 (PLT),血栓激素时间 (TT) 和纤维素原 (Fib) 是HDP的独立预后因素.
- 患有HDP的孕妇表现出更高的不良结果率,包括早产,产后出血和胎儿生长限制.
结论:
- 输血组时间 (PT),激活的部分血栓形成时间 (APTT),TT,Fib和国际规范化比率都表明了HDP的严重程度.
- 凝血参数为HDP状态和预后提供了有价值的见解.
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