埃斯库林通过Nrf2/HO-1信号传递来缓解棕酸诱导的肠壁损伤
Qinglan Song1, Yongbo Wang1, Yexin Tang1
1Department of Gastroenterology, Taishun County People's Hospital Taishun 325500, Zhejiang, China.
American journal of translational research
|March 17, 2025
概括
埃斯库林通过减少炎症和激活Nrf2/HO-1通路来保护对棕酸诱导的肠壁损伤. 这项研究突出了ESCULIN.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 药理学和毒理学 药理学和毒理学
- 分子生物学分子生物学
背景情况:
- 肠道屏障的破坏与各种胃肠道疾病有关.
- 棕酸可以引起肠道屏障的损伤.
- 埃斯库林是一种具有潜在治疗功能的天然化合物.
研究的目的:
- 在小鼠模型中研究埃斯库林对棕酸诱导的肠道屏障破坏的保护作用.
- 阐明埃斯林作用的基本机制,重点关注炎症和信号通路.
主要方法:
- 通过使用棕酸来诱导肠道屏障损伤,建立了一个小鼠模型.
- 小鼠接受了埃斯库林治疗,另一个小组也接受了ML385来研究特定的途径.
- 分析了疾病活动指数 (DAI),血清细胞因子水平 (TNF-α,IL-1β,IL-6),氧化应激标志物 (MDA,T-AOC) 和肠道组织标志物 (mRNA和奥克卢丁蛋白的蛋白质表达,ZO-1,Nrf2,HO-1).
主要成果:
- 埃斯库林治疗显著降低了DAI和TNF-α,IL-6和IL-1β的血清水平.
- 埃斯库林治疗增加了抗氧化能力 (T-AOC) 和降低了脂质过氧化 (MDA).
- 肠道粘膜显示ZO-1,Nrf2,HO-1和奥克卢丁的表达增加,ML385扭转了这些影响.
结论:
- 埃斯库林有效地减轻了小鼠的棕酸诱导的肠壁损伤.
- 保护机制包括Nrf2/HO-1信号通路的激活和炎症反应的抑制.
- 埃斯库林显示出作为治疗肠道屏障功能障碍的治疗剂的潜力.
相关概念视频
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.0K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.0K
01:23Renewal of Intestinal Stem Cells
2.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.5K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
01:24Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
353
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
353
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
329
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
329
02:26NF-κB-dependent Signaling Pathway
7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.2K