评估二异尼尔他酸的内分泌干扰潜力
I A Lea1, A N Buerger1, D Feifarek1
1ToxStrategies LLC, 31 College Place Suite B118, Asheville, NC 28801, USA.
Current research in toxicology
|March 17, 2025
概括
双异尼尔甲酸盐 (DINP) 不符合作为内分泌干扰剂的标准. 证据权重评估发现雌激素,雌激素或类固醇生成途径没有不良结果,表明DINP不是内分泌干扰物.
科学领域:
- 环境毒理学环境毒理学
- 内分泌干扰 干扰内分泌系统
- 化学安全评估 化学安全评估
背景情况:
- 低分子量甲甲酸盐是已知的内分泌干扰剂.
- 双异尼尔甲酸盐 (DINP) 是一种大量生产的化学物质.
- 了解DINP的内分泌干扰潜力对于公共卫生至关重要.
研究的目的:
- 评估二异尼尔甲酸盐 (DINP) 和其代谢产物的内分泌干扰潜力.
- 评估DINP对雌激素,雌激素,甲状腺和类固醇生成途径的影响.
- 根据ECHA/EFSA指南,确定DINP是否符合内分泌干扰剂的标准.
主要方法:
- 根据ECHA/EFSA内分泌干扰剂指南 (2018年) 的证据权重评估.
- 从110篇文章和105个高通量试验中对毒理学数据的审查.
- 对DINP代谢物的EATS活性和不良结果途径 (AOP) 框架分析的in-silico评估.
主要成果:
- 在体内,DINP没有引起不良的雌激素或甲状腺相关结果.
- 在体内评估甲状腺通路时存在数据缺口.
- 对于不良的雄激素或类固醇生成途径,没有发现生物学上可信的联系或剂量一致性.
结论:
- DINP不符合ECHA/EFSA的标准,被归类为内分泌干扰剂.
- 证据表明DINP不会破坏雌激素,雌激素或类固醇生成途径.
- 可能需要对甲状腺通路进行进一步的研究,以充分解决数据缺口.
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