在急性冠状动脉综合征患者中通过主动和解改善药物安全:一项随机试验
Mahdieh Fatemi-Nejad1, Maryam Mehrpooya1, Davoud Ahmadimoghaddam2
1Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Exploratory research in clinical and social pharmacy
|March 17, 2025
概括
积极的药物调和模型显著减少了急性冠状动脉综合征 (ACS) 患者的药物错误,而不是追溯的方法. 这种方法更节省时间,并防止更多的无意差异,提高了患者的安全性.
科学领域:
- 心血管医学 心血管医学
- 临床药房 临床药房
- 患者安全 患者安全
背景情况:
- 患有急性冠状动脉综合征 (ACS) 的患者由于复杂的治疗方案和护理过渡而面临药物错误的高风险.
- 高风险的药物和患者的脆弱性进一步提高了不良事件的可能性.
研究的目的:
- 为了比较主动与追溯药物调和的有效性和时间效率,以防止住院ACS患者的无意药物差异.
- 评估不同调和模型对药物错误率和潜在危害的影响.
主要方法:
- 一个随机对照试验,涉及到心血管教学医院的162名ACS患者.
- 患者被分配到由临床药剂师领导的前性或追溯性药物调和组.
- 收集的数据包括无意的药物差异,潜在的伤害和时间效率.
主要成果:
- 主动模型发现的非故意的药物差异显著减少 (13%与44%,p < 0.001),并且每个患者的平均数量更低 (0.6与1.7,p < 0.001).
- 积极组中较少的患者出现了差异 (38.3%与66.7%,p < 0.001),大多数错误是轻微的.
- 医生报告说,他们对主动方法的满意度更高,这种方法也显示出更高的时间效率.
结论:
- 积极的药物调和模型在预防ACS患者的无意药物差异方面更有效和更节省时间.
- 实施主动和解可以提高患者的安全性,并减少这种脆弱人群中药物错误的风险.
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