据推测患有肺结核的儿童的人体成长轨迹
M V de Geus1,2, M van Niekerk1, C McKenzie1
1Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
IJTLD open
|March 17, 2025
概括
患有结核病 (TB) 的儿童的身高相对年龄的Z分数 (HAZ) 较低,体重不足的情况更频繁. 改善儿童整体营养对于改善结核病患者的长期健康结果至关重要.
科学领域:
- 儿童传染病 儿童传染病
- 营养科学 营养科学
- 增长监测 增长监测是指对增长的监测.
背景情况:
- 肺结核 (TB) 严重影响儿童的发育.
- 评估生长轨迹对于了解儿童结核病的长期影响至关重要.
- 早期发现和干预是减轻疾病影响的关键.
研究的目的:
- 为了评估患有肺结核 (PTB) 的儿童的生长模式.
- 为了比较结核病儿童,症状对照组和健康对照组之间的人类测量和Z分数.
- 确定与儿童PTB相关的营养缺陷和生长迟缓.
主要方法:
- 南非Umoya结核病诊断研究 (2017-2021) 的一个子研究.
- 招募和12个月的跟踪0-13岁的儿童的推定PTB.
- 定期的人类测量测量 (体重,身高,BMI) 和Z-score计算 (WAZ,HAZ,BAZ) 分析使用多变量混合效应线性回归.
主要成果:
- 在372名儿童中,153人患有结核病,168人有症状,51人是健康的对照.
- 与对照组相比,患有结核病的儿童的身高对年龄Z分数 (HAZ) 显著降低 (P=0.0037).
- 虽然结核病患者的体重-年龄Z分数 (WAZ) 随着时间的推移而有所改善,但HAZ没有显著变化,表明持续的线性生长缺陷.
结论:
- 患有结核病的儿童表现出显著的线性生长缺陷 (较低的HAZ),尽管体重可能有所改善.
- 与症状和健康对照组相比,结核病儿童的体重不足率更高.
- 改善儿童的营养状况对于改善结核病和其他儿童疾病的长期结果至关重要.
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