和注入假牙基树脂的生物相容性和抗菌性质
Rajul Vivek1, Sarita Aneja2, Sneha Amit Rathi3
1Department of Prosthodontics & Crown and Bridge, Purvanchal Institute of Dental Sciences, Gorakhpur, Uttar Pradesh, India.
Bioinformation
|March 17, 2025
概括
和可以增强假牙基质树脂,提高生物相容性,减少微生物生长. 与和标准PMMA树脂相比,注入的树脂显示出更高的细胞活力和抗菌作用.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 纳米技术纳米技术
背景情况:
- 聚甲基甲酸 (PMMA) 假牙基树脂缺乏固有的生物活性,易受微生物殖民.
- (Ti) 和 (Zr) 具有生物相容性和抗菌特性,有利于牙科应用.
- 用Ti和Zr增强PMMA可以改善假牙基材的性能和患者的治疗结果.
研究的目的:
- 为了评估Ti和Zr注入的PMMA假牙基树脂的生物相容性和抗菌疗效.
- 为了比较Ti和Zr注入树脂与传统PMMA的性能.
- 确定Ti和Zr作为先进假牙材料的添加剂的潜力.
主要方法:
- 制备了三组假牙基质树脂:PMMA控制,PMMA+5重%Ti和PMMA+5重%Zr.
- 使用MTT测定对72小时的人类牙纤维细胞 (HGFs) 进行生物相容性评估.
- 通过殖民地形成单元 (CFU) 测定,对*Streptococcus mutans*和*Candida albicans*进行抗菌活性测试.
主要成果:
- 在72小时后,Ti注入的树脂显示了85%的HGF活力 (25%的增长与对照).
- 与对照组相比,Zr注入树脂显示HGF活力增加了15%.
- 注入的树脂减少了*S. mutans*的60%和*C. albicans*的45%;Zr注入的树脂分别减少了40%和30%.
结论:
- 与传统的PMMA相比,Ti和Zr注入的假牙基树脂具有增强的生物相容性和显著的抗菌特性.
- 注入的树脂提供了卓越的生物效益,表明牙材料增强的强大潜力.
- 将Ti和Zr纳入假牙基材可以提高临床性能和患者满意度.
相关概念视频
01:29Biofilms
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...