对印度儿科患者中黄金葡萄球菌感染的分析
Priyank Rajan1, Nayan Chaudhary2, Mukesh Sanklecha3
1Clinical Fellow in Paediatric Haematology Oncology and BMT, Bristol Royal Hospital for Children, Bristol, United Kingdom.
黄金葡萄球菌感染在住院儿童中很常见. 殖民,特别是鼻腔和腔,是危险因素,甲素耐药黄金葡萄球菌 (MRSA) 呈现出增加的耐药性,尽管万科米辛和提科普拉宁仍然有效.
科学领域:
- 儿童传染病 儿童传染病
- 临床微生物学 临床微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 黄金葡萄球菌 (Staphylococcus aureus) 是儿童群体中重要的病原体,导致各种感染.
- 甲素耐药黄金葡萄球菌 (MRSA) 的增加给治疗和控制带来了挑战.
- 了解当地流行病学,包括殖民和抵抗模式,对于有效管理至关重要.
研究的目的:
- 为了调查住院儿童的金黄色葡萄球菌感染.
- 为了确定殖民模式和抗生素敏感性概况.
- 评估MRSA与甲素敏感黄金葡萄球菌 (MSSA) 的流行情况.
主要方法:
- 对103名儿科患者 (感染者和对照) 的前性观察研究.
- 从临床标本中收集的金黄色菌种分离物.
- 通过鼻腔,下,喉和 inguinal swabs 评估殖民.
- 使用MIC方法进行的抗生素敏感性测试.
主要成果:
- 在31.06%的患者中确认了金黄色细菌感染;71.87%的感染病例显示殖民.
- 鼻腔和腔区域是最常见的殖民地点.
- MRSA占感染的46.8%;MRSA分离体表现出比MSSA更高的抗生素耐药性.
- 范科米辛,达普托米辛和提科普拉宁对MRSA和MSSA均表现出100%的疗效.
结论:
- 殖民是S. aureus感染的重要危险因素在儿科患者中.
- 在这个队列中,万科米辛和提科普拉宁仍然是对MRSA的有效治疗方法.
- 耐药性增加需要仔细选择抗生素,并在儿科护理环境中加强预防策略.
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