用冷大气等离子体推进慢性和急性伤口愈合:细胞和分子机制,益处,风险和未来方向
Nastaran Raissi-Dehkordi1, Negar Raissi-Dehkordi1, Hamed Ebrahimibagha1
1Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Frontiers in medicine
|March 17, 2025
概括
冷大气等离子体 (CAP) 疗法通过调节炎症,刺激组织修复和对抗感染来加速伤口愈合. 这种非侵入性方法对慢性和急性伤口都有希望,改善了患者的治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 皮肤病学 皮肤病学
背景情况:
- 慢性和急性伤口带来了重大的医疗保健挑战,导致长时间的康复和并发症.
- 糖尿病足,静脉腿,手术切口和烧伤是需要先进治疗的常见例子.
- 目前的疗法经常与持续的感染和生物膜形成作斗争,阻碍有效的愈合.
研究的目的:
- 审查冷大气等离子体 (CAP) 促进伤口修复的细胞和分子机制.
- 探索CAP作为慢性和急性伤口的非侵入性治疗方式的潜力.
- 讨论CAP在伤口管理中的临床应用,挑战和未来方向.
主要方法:
- 对研究CAP对伤口愈合的影响的文献综述.
- 分析CAP对细胞过程的影响,包括炎症,血管新生和组织重塑.
- 检查CAP对伤口病原体和生物膜的抗菌特性.
主要成果:
- CAP调节炎症,刺激血管生成,并促进组织重塑,加速再生.
- CAP表现出抗菌作用,减少细菌负载并防止生物膜的形成.
- 临床研究表明,CAP在改善各种伤口类型的愈合指标方面具有有效性.
结论:
- 冷大气等离子体是一种安全有效的创伤治疗的非侵入性疗法.
- 在慢性和急性伤口护理方面,CAP具有显著的潜力,可以改善患者的治疗结果.
- 需要进一步的研究来规范协议,确保长期安全,并开发便携式设备,以广泛采用临床.
相关概念视频
Phases of Wound Repair
5.8K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
5.8K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K


