相关实验视频
Updated: May 22, 2025

10:09
In Ovo and Ex Ovo Methods to Study Avian Inner Ear Development
Published on: June 16, 2022
2.3K
诺奇连接体Jagged1在耳毛细胞再生中起着双重作用
bioRxiv : the preprint server for biology
|March 17, 2025
概括
Jagged1 (JAG1) 痕信号传递在耳支细胞 (SC) 中保留了原始细胞特征,这对于毛细胞 (HC) 再生至关重要. 刺激这种途径可以提高哺乳动物的HC再生潜力,为治疗聋提供希望.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 发展生物学 发展生物学
- 再生医学是一种再生医学.
背景情况:
- 哺乳动物的耳毛细胞 (HCs) 对于听力至关重要,但不能再生.
- 失去了HCs是人类聋的主要原因.
- 新生儿的耳支细胞 (SCs) 可以再生HCs,但Notch信号抑制了这一过程.
研究的目的:
- 研究Jagged1 (JAG1) / Notch信号在耳支细胞 (SCs) 中的作用,以及它们在毛细胞 (HC) 再生方面的潜力.
- 确定JAG1/Notch信号如何影响SC原生特征和HC-fate抑制.
主要方法:
- 利用一个有机体平台研究耳细胞相互作用.
- 进行了转录和机械学研究,以分析基因表达和信号通路.
- 在耳扩展器和体内模型中使用了JAG1-Fc刺激.
主要成果:
- JAG1/Notch信号保留了耳SCs的祖先类特征,而不是仅仅抑制HC命运.
- 这种信号通路维持了SCs中原生基因和代谢基因的表达.
- 由Notch1和Notch2介导的JAG1/Notch信号维持了促进生长的途径,包括PI3K-Akt-mTOR,由Notch1和Notch2介导.
结论:
- JAG1/Notch信号传输对于保持耳SCs的原始状态至关重要.
- 刺激JAG1/Notch信号增强了SCs再生HCs的能力.
- 这一发现为促进毛细胞再生和治疗听力损失提供了潜在的治疗策略.
相关概念视频
Notch Signaling Pathway
4.2K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.2K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.0K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.0K
Hair Cells
39.9K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
39.9K
Hedgehog Signaling Pathway
7.3K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.3K
The Cochlea
44.4K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
44.4K
Hearing
51.7K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
51.7K

