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Updated: May 22, 2025

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
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Th1/Th17轴调节了仿制抗原受体 (CAR) 的T细胞治疗毒性

Payal Goala, Yongliang Zhang, Cooper Sailer

    bioRxiv : the preprint server for biology
    |March 17, 2025
    PubMed
    概括

    通过阻断干扰素- (IFNγ) 可以减少CAR-T治疗的副作用,包括细胞因子释放综合征 (CRS) 和中性质衰竭. 这种方法可以减轻毒性,而不会损害CAR-T细胞的疗效,提供了潜在的新治疗策略.

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