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Updated: May 22, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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一种强效和选择性的TNKS2抑制剂,用于瘤选择性WNT抑制

Jill Zimmerman1,2, Brandon F Malone3, Efrat Finkin-Groner4

  • 1Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, 10021.

bioRxiv : the preprint server for biology
|March 17, 2025
PubMed
概括

染色体8p丢失的瘤对基酶2 (TNKS2) 抑制具有脆弱性. 这允许在癌细胞中选择性抑制WNT通路,为表皮性恶性瘤提供了一种新的治疗策略.

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