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Updated: May 22, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

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AF3复合的收益提高了蛋白质复合体的结构预测

Jonathan Feldman1,2, Jeffrey Skolnick2

  • 1Center for the Study of Systems Biology/School of Biological Sciences, Georgia Institute of Technology, 950 Atlantic Drive, 30332, Georgia.

bioRxiv : the preprint server for biology
|March 17, 2025
PubMed
概括

在AlphaFold 3上构建的AF3Complex准确预测蛋白质复杂结构,在基准测试中表现优于其前身和其他模型. 这种新工具增强了对生物通路的理解,并且可以免费使用.

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Protein Complexes with Interchangeable Parts

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Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Protein Organization

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The primary structure of a protein is its amino acid sequence....
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Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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