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Updated: May 22, 2025

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
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A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Published on: October 16, 2018

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辅助刺激领域影响了B细胞恶性瘤中CD19 CAR-T细胞耐药性的发展

Marta Krawczyk1,2,3, Narcis Fernandez-Fuentes4, Klaudyna Fidyt2,4

  • 1Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.

bioRxiv : the preprint server for biology
|March 17, 2025
PubMed
概括

针对B细胞恶性瘤的CAR-T疗法表现出耐药性,通常是由于CD19抗原损失. 这项研究揭示了4-1BBCAR-T细胞驱动CD19突变,与CD28CAR-T细胞不同,影响治疗结果.

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