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Updated: May 22, 2025

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
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Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases

Published on: February 24, 2018

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三基扎尔多克西姆是ThDP依赖的DXP合成酶的氧化还原循环抑制剂

Charles R Nosal1,2, Ananya Majumdar3, Netzahualcóyotl Arroyo-Currás1,2

  • 1Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

bioRxiv : the preprint server for biology
|March 17, 2025
PubMed
概括

三基双胺通过诱导乳酸-ThDP脱氧化来抑制细菌的1-Deoxy-d-xylulose-5-phosphate合成酶 (DXPS). 这些化合物在有氧条件下作为氧化还原循环抑制剂,为药物开发提供了新的策略.

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In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
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