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Updated: May 22, 2025

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
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Published on: June 26, 2013

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主要神经退行性疾病共享的广泛的神经元基因组损伤的反复出现模式

Zinan Zhou1,2, Lovelace J Luquette3, Guanlan Dong1,2,4

  • 1Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.

bioRxiv : the preprint server for biology
|March 17, 2025
PubMed
概括

像ALS,FTD和AD这样的神经退行性疾病显示神经元中体质突变的增加. 拓酶1 (TOP1) 活性可能驱动这些突变,这表明神经元死亡的常见途径.

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