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Updated: May 22, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Published on: November 15, 2013

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将PPARγ形态组合转移到转录抑制状态,可以提高共价抑制剂的有效性

Liudmyla Arifova1,2, Brian S MacTavish3, Zane Laughlin2

  • 1Undergraduate Program in Biochemistry and Chemical Biology, Vanderbilt University, Nashville, Tennessee, United States.

bioRxiv : the preprint server for biology
|March 17, 2025
PubMed
概括

过氧酶增殖器激活受体 (PPARγ) 的共价抑制剂可以通过全性机制削弱但不能完全阻断连接体结合. 新的反向激动剂稳定压制性构造,为设计更有效的PPARγ抑制剂提供了洞察力.

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