饮食中的植物多样性预测了生命早期微生物群的成熟
medRxiv : the preprint server for health sciences
|March 17, 2025
概括
补充养塑造了婴儿肠道微生物组的发展. 早期的饮食,而不是多样性,预测了类似成人的细菌,支持两阶段微生物组成熟模型.
科学领域:
- 微生物组研究的研究.
- 婴儿营养 婴儿营养
- 全球卫生健康 全球卫生健康
背景情况:
- 婴儿肠道微生物群对健康至关重要,但补充养如何影响其发展尚未完全理解.
- 饮食模式在全球范围内有所不同,但它们对不同种群的早期微生物殖民的影响需要进一步调查.
研究的目的:
- 研究全球不同地区的补充养实践与婴儿肠道微生物组之间的关系.
- 确定在生命早期塑造正在发展的肠道微生物群的关键饮食因素.
主要方法:
- 利用基于DNA的方法FoodSeq,评估来自不同地理位置 (北美/中美洲,非洲,亚洲) 的729名0-3岁儿童的食物摄入量.
- 分析饮食数据以确定常见和独特的食物序列和饮食轨迹.
- 与肠道微生物组成相关的饮食模式.
主要成果:
- 检测到199种独特的植物食物序列,只有8种主食在全球范围内共享,突出显著的饮食变化.
- 尽管存在差异,但早期的饮食遵循了一个共同的轨迹,断奶阶段是主导的饮食特征.
- 饮食多样性与肠道微生物多样性没有相关性;然而,饮食多样性和断奶阶段预测了成人相关细菌的丰富性.
结论:
- 这些发现支持一个分为两个阶段的婴儿微生物组成熟模型:一个初始的牛奶主导阶段,然后是对饮食反应的阶段,导致成人类社区.
- 监测和促进婴儿的植物性饮食多样性可能是全球支持及时微生物组成熟的关键.
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