一个单一的语义行为综合索引随着时间的推移跟踪精神病的症状
Claudio Palominos1, Maryia Kirdun1, Amir H Nikzad2,3
1Department of Translation & Language Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
medRxiv : the preprint server for health sciences
|March 17, 2025
概括
一个来自语音的新语义索引有效地跟踪精神分裂症谱系障碍 (SSD) 和随着时间的推移它们的症状. 这一单一指标简化了精神病中复杂的语言分析,有助于诊断和治疗监测.
科学领域:
- 心理语言学 心理语言学
- 计算语言学 计算语言学
- 临床心理学 临床心理学
背景情况:
- 精神分裂症谱系障碍 (SSD) 在语言中表现出异常的语义关联.
- 来自语音分析的高维度语义空间对理解和应用提出了挑战.
- 现有的方法缺乏统一的,单个级别的追踪机制来追踪SSD中的语义变化.
研究的目的:
- 从自发言语中开发一个单一的复合语义索引.
- 评估该指数是否能够随着时间的推移跟踪SSD患者的诊断和症状概况.
- 简化复杂的语义空间,以实现理论和实践方面的进步.
主要方法:
- 主要组件分析 (PCA) 用于从117个语义变量中导出一个复合索引.
- 该指数在SSD和健康对照 (HC) 个体的言论样本上进行了测试.
- 数据包括103名SSD和36名HC患者的四个时间点,他们执行图片描述任务.
主要成果:
- 复合语义索引有效地区分了SSD和HC组.
- 该指数确定了急性精神病,缓解和稳定之间的过渡.
- 它预测了思维,语言和沟通 (TLC) 指数得分的65%的差异.
结论:
- 一个单一的复合语义索引有意义地总结了精神病中的语义转变.
- 这个指数跟踪症状严重程度和诊断状态随着时间的推移在个人层面.
- 无法解释的差异表明精神病中涉及其他语义和非语义因素.
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