血清视网醇结合蛋白与下肢动脉硬化风险在2型糖尿病中存在关联
Yu-Ling Zhang1,2, Gui-Liang Peng1, Wei-Ling Leng1
1Department of Endocrinology, Southwest Hospital, Army Medical University (The Third Military Medical University), Chongqing 400038, China.
World journal of diabetes
|March 17, 2025
概括
血清视网醇结合蛋白 (RBP) 水平升高与2型糖尿病 (T2DM) 患者下肢动脉硬化风险更高有关. 这一发现强调了RBP作为这种疾病的潜在生物标志物.
科学领域:
- 内分泌学和新陈代谢学
- 血管生物学 血管生物学
- 营养生物化学 营养生物化学
背景情况:
- 血清视网醇结合蛋白 (RBP) 对于维生素A的运输和维持生理平衡至关重要.
- RBP与糖尿病进展及其并发症有关.
- 在2型糖尿病 (T2DM) 中,RBP和下肢动脉样硬化之间的关联仍然不清楚.
研究的目的:
- 为了研究血清RBP水平与T2DM患者下肢动脉样硬化的存在之间的关系.
- 评估RBP作为下肢动脉硬化的潜在预测因子.
主要方法:
- 对4428名T2DM患者的回顾性分析,通过下肢动脉超声波进行分类.
- 在入院时测量了血清RBP水平,并将患者分为三分组 (Q1-Q3).
- 统计分析包括后勤回归,限制立方线,子组分析和机器学习.
主要成果:
- 超过一半 (56.80%) 的T2DM患者患有下肢动脉样硬化.
- 较高的血清RBP水平与较高的下肢动脉样硬化风险相关 (OR=1.01每单位增加).
- 患有最高RBP第三位 (Q3) 的患者与最低 (Q1) (OR=1.36) 相比,风险明显更高.
结论:
- 血清RBP水平升高与T2DM患者下肢动脉样硬化风险增加有关.
- 血清RBP可以作为一种有价值的生物标志物,用于预测T2DM下肢动脉样硬化.
- 进一步的研究可以探索RBP在这种血管并发症中的机械作用.
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