针对结直肠癌的重用酸 (HCTZ):一个回顾性和单一中心研究
Dominic Chi-Chung Foo1, Jiaxi Li1, Zheng Huang1
1Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Frontiers in pharmacology
|March 17, 2025
概括
甲酸 (HCTZ) 治疗与大肠直肠癌 (CRC) 患者的生存率改善和复发率降低有关. 这一发现表明HCTZ可能为CRC患者提供更好的预后,特别是那些晚期或老年人.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 抗高血压药物表现出抗炎和抗血管原性质.
- 研究抗高血压药物对结直肠癌 (CRC) 患者结局的影响至关重要.
研究的目的:
- 检查抗高血压药物使用与结直肠癌 (CRC) 患者的预后之间的关联.
- 为了比较不同抗高血压药物组的生存数据和免疫细胞种群.
主要方法:
- 检索了1134名接受治疗手术的高血压CRC患者的临床数据 (2005-2015年).
- 在各种抗高血压药物治疗方案和整体CRC患者队列中比较生存数据和循环免疫细胞种群.
主要成果:
- 与一般CRC人群 (58.2%) 相比,接受抗高血压药物治疗的患者的5年整体存活率更高 (65.2%).
- 甲 (HCTZ) 显示出最佳预后 (79.1%),显著改善了晚期或老年患者的治疗结果.
- HCTZ治疗与较低的复发率 (18.3%) 与非HCTZ使用者 (26.8%) 相比.
- 在接受HCTZ治疗的患者中,较低的手术前基因细胞水平与更好的整体和无疾病生存率相关.
结论:
- 甲酸 (HCTZ) 治疗与结直肠癌 (CRC) 患者的预后明显改善有关.
- HCTZ可能是一种有益的治疗选择,可以改善CRC患者的治疗结果,特别是在特定的患者子组中.
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