大脑体积计分析与泰国老年人的衰老变化和性别差异有关
Weerasak Muangpaisan1, Chanon Ngamsombat2, Yudthaphon Vichianin3
1Division of Geriatrics, Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Dementia and geriatric cognitive disorders extra
|March 17, 2025
概括
在55岁以上的成年人中,大脑结构和心室体积随年龄和性别而变化. 这些发现为临床解释和理解大脑衰老提供了规范性参考.
科学领域:
- 神经成像是一种神经成像.
- 老年学是一门学科.
- 神经学 神经学
背景情况:
- 关于与年龄和性别相关的大脑体积变化的规范性数据对于研究和临床应用至关重要.
- 了解结构性大脑变化对于识别认知衰退和神经系统疾病至关重要.
研究的目的:
- 在55岁及以上的成年人中建立结构性大脑体积变化的规范性数据.
- 研究年龄和性别对大脑结构和心室体积的影响.
主要方法:
- 这是一项前性,两中心的队列研究,对201名年龄在55-85岁之间的认知正常成年人进行了研究.
- 使用MRI扫描的FreeSurfer软件对大脑结构进行定量体积测量.
- 分析临床数据和神经心理测试,以排除认知障碍的参与者.
主要成果:
- 发现海马体,大脑体,丘脑体和心室的年龄和体积之间存在显著的相关性 (p<0.05).
- 在特定年龄组 (p<0.05) 中观察到总内体积,尾状体,叶和心室体积的显著性别差异.
结论:
- 年龄和性别是影响大脑结构和心室体积的重要因素.
- 生成的规范性数据可以作为对85岁以下的个体临床解释的参考.
- 这些发现有助于理解与衰老相关的生理大脑变化.
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