在南非研究患有癌症的儿科患者的听力功能
Tlangelani Nyeleti Chauke1, Katijah Khoza-Shangase1
1Department of Audiology, School of Human and Community Development, University of the Witwatersrand, Johannesburg, South Africa.
概括
基于的化疗会导致癌症儿童的听力损失. 在南非,有限的资源阻碍了听力学监测,导致未经治疗的听力损伤. 早期检测对于生活质量至关重要.
科学领域:
- 癌症治疗对儿科患者的耳毒性影响.
- 在资源有限的医疗保健机构进行听力学评估.
背景情况:
- 接受基化疗的儿童癌症患者面临着耳毒性和永久性听力损失的高风险.
- 在南非,常规的听力学监测是具有挑战性的,可能会导致未经诊断的听力障碍.
研究的目的:
- 为了研究在南非接受化疗的儿童癌症患者的听力功能.
- 评估与癌症治疗相关的听力损失的患病率和特征.
主要方法:
- 从47名儿科癌症患者 (5-18岁) 的听力学记录的回顾性审查.
- 听力值, tympanometry 和扭曲产品的耳声发射 (DPOAE) 的分析.
- 后勤回归以确定西斯治疗与听力损失之间的关联.
主要成果:
- 36.2%的患者在治疗后出现了高频感应神经神经听力损失,频率在4000-8000Hz之间变化.
- 西斯普拉丁治疗与听力损失有显著的相关性 (OR=3.18,p=0.003).
- DPOAE证实了外皮毛细胞功能障碍,表明耳损伤.
结论:
- 南非儿童癌症患者中很大一部分患有因耳毒性治疗导致的高频听力损失.
- 标准化的听力监测协议是必不可少的,特别是在资源有限的环境中.
- 早期发现和管理可以减轻听力损失对发展和生活质量的影响.
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