相关实验视频
Updated: May 22, 2025

Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
单独注射鼻内胰岛素膜和联合注射鼻内胰岛素加类固醇膜之间的比较,用于病毒后嗅觉功能障碍
Khalaf Hamead1, Mostafa Ismail Ahmed1, Abdel Rahim Ahmed Abdel Karim1
1Otorhinolaryngology, Faculty of Medicine, Minia University, Minia, Egypt.
鼻内胰岛素膜改善了COVID后的嗅觉功能障碍. 在快溶膜中将胰岛素与布德索尼德结合使用,与单独胰岛素相比,显著增强了嗅觉恢复.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 后病毒性嗅觉功能障碍,特别是在COVID-19之后,是一个持久的问题.
- 嗅觉粘膜中的胰岛素受体表明胰岛素对嗅觉神经元再生的潜力.
- 鼻内胰岛素治疗正在研究治疗嗅觉障碍.
研究的目的:
- 为了比较病毒后嗅觉功能障碍的鼻内胰岛素膜.
- 为了评估添加布索尼德到鼻内胰岛素膜的疗效.
- 为了评估组合配方的恢复率.
主要方法:
- 250名患有病毒后嗅觉功能障碍的患者被分为两组.
- 组A (125名患者) 接受了鼻内胰岛素 (100IU) 和布松胺 (10mg).
- B组 (125名患者) 仅接受了鼻内胰岛素 (100 IU),通过快速溶解的薄膜输送.
主要成果:
- 这两组在鼻内注射胰岛素膜后,都显示了嗅觉的改善.
- 接受联合胰岛素和布索尼德薄膜的组显示嗅觉恢复显著改善.
- 统计分析表明,组合治疗组的p值<0.001.
结论:
- 鼻内胰岛素治疗对后病毒性嗅觉障碍有效,改善嗅觉值和歧视.
- 在快速溶解的鼻内膜中将布德索尼德与胰岛素结合起来,可以获得更好的治疗效果.
- 这种组合疗法为治疗病毒后嗅觉功能障碍提供了一个有希望的方法.
更多相关视频
15:04Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Published on: May 20, 2016
07:28Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
相关概念视频
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Inhaled Medications
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...