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维生素B对精神分裂症症状和认知功能的影响:一个随机,双盲,安慰剂控制的临床试验
Somayeh Agmashe1, Gita Sadighi2, Narges Radman3
1Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Iranian journal of psychiatry
|March 17, 2025
概括
这项研究发现,辅助维生素B治疗在12周内显著减少了慢性精神分裂症患者的负面症状. 积极和认知症状没有显著改善,这表明针对特定精神分裂症症状有针对性的好处.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 营养精神病学 营养精神病学
背景情况:
- 精神分裂症是一种慢性精神疾病,通常用抗精神病药物治疗.
- 营养缺乏,特别是B族维生素,与精神分裂症的发展有关.
- 维生素B作为辅助疗法的潜在作用需要研究.
研究的目的:
- 评估B族维生素补充作为慢性精神分裂症抗精神病治疗辅助剂的疗效.
- 评估维生素B对精神分裂症负面,积极和认知症状的影响.
主要方法:
- 进行了一项为期12周的随机,双盲,安慰剂对照试验.
- 25名慢性精神分裂症患者接受了B族维生素 (B1,B2,B6,B12,尼古丁胺) 以及抗精神病药物.
- 另外25名患者接受了安慰剂加上抗精神病药物,在基线和第4,8和12周进行了症状评估.
主要成果:
- 辅助维生素B治疗导致12周后负面症状的统计显著减少 (P < 0.0001).
- 观察到积极和认知症状改善的趋势,但没有达到统计学意义.
- 没有报告任何可能对使用维生素B进行禁忌的不良反应.
结论:
- 组B维生素,当用作抗精神病药物的辅助剂时,显示出改善慢性精神分裂症负面症状的潜在益处.
- 需要进一步的研究来探索对积极和认知症状以及长期结果的影响.
- 补充维生素B是一种有希望的辅助策略,用于管理精神分裂症的特定症状领域.
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