虫:一种主要的机会主义真菌病原体的多药性耐药性和增加的毒性
Michael A Pfaller1,2, Mariana Castanheira2, Shawn R Lockhart3
1JMI Laboratories, North Liberty, Iowa, USA.
Current fungal infection reports
|March 17, 2025
概括
氏体感染正在上升,对常见的抗真菌药物如可纳的耐药性增加. 遗传突变正在增强其毒性,并导致多药性耐药性,这构成了重大的临床挑战.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 虫 Candida glabrata 是血源性传播虫病 (HDC) 的重要原因,特别是在美国.
- 自1992年以来,C. glabrata感染和富可纳耐药性的记录有所增加.
- 虽然C. glabrata的毒性通常不如Candida albicans,但C. glabrata的毒性正在重新评估中.
研究的目的:
- 为了强调Candida glabrata中抗真菌耐药性的日益增长的流行.
- 为了引起人们对C. glabrata临床分离物中出现的多药性耐药性 (MDR) 的注意.
- 为了强调对醇和类素的共同耐药性的临床意义.
主要方法:
- 对C. glabrata感染和抗真菌耐药性趋势的流行病学数据的分析.
- 对影响C. glabrata的基因突变 (例如,CgPdr1pGOF突变) 的最新发现的审查.
- 检查来自多中心调查的临床隔离数据.
主要成果:
- 自1992年以来,C. glabrata的频率增加是HDC的原因,并且在美国增加了流可纳耐药性.
- 在CgPdr1p中获得功能的突变赋予了阿醇耐药性,并增强了C. glabrata的适应性和毒性.
- 在临床C. glabrata分离物中出现多药性耐药性 (MDR) 和对醇和素的共同耐药性.
结论:
- 由于抗真菌耐药性和毒性增加,Candida glabrata构成越来越大的威胁.
- 遗传修饰正在推动C. glabrata中MDR的出现.
- 对主要抗真菌类的共同耐药性需要紧急临床关注和治疗策略的开发.
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