在使用Crotalidae多价免疫Fab (CroFab) 后发生过敏反应
Lena Truong1, Takla R Anis1, Layla Najibfard1
1Pharmacy Department, Henry Mayo Newhall Hospital, Valencia, CA, USA, Emergency Department, Henry Mayo Newhall Hospital, Valencia, CA, USA.
Clinical pharmacology : advances and applications
|March 17, 2025
概括
对Crotalidae多价免疫Fab (CroFab) 的过敏反应可能发生,即使输液缓慢. 这一案例突出了一个患有CroFab过敏症的患者,但耐受了另一种马类抗毒药,ANAVIP.
科学领域:
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 克罗塔利多价免疫Fab (CroFab) 是美国食品和药物管理局批准的抗毒剂,用于北美坑蛇毒害.
- 虽然广泛使用,但CroFab.的过敏反应包括I型,IV型和血管已经被记录在案.
- 及时识别和管理不良反应对于患者的安全至关重要.
研究的目的:
- 报告一个严重过敏反应对CroFab的病例.
- 为了说明不同抗毒剂配方之间的交叉反应或耐受性差异的潜力.
- 强调严重药物不良反应的多学科管理的重要性.
主要方法:
- 一个41岁的男性在CroFab输注期间出现过敏反应的案例研究.
- 临床观察包括呼吸困难和口腔胀等症状.
- 用CroFab进行支持性护理和重新挑战,随后使用替代抗毒剂 (ANAVIP).
主要成果:
- 在开始CroFab输液后不久,患者出现过敏反应症状.
- 症状随着CroFab的立即停止和上腺素,皮质类固醇和抗胰岛素的使用而消失.
- 再次服用CroFab,即使速度较慢,也会引发类似的反应.
- 患者可以耐受虫免疫F(ab') 2 (马) 抗毒剂 (ANAVIP),没有副作用.
结论:
- 对CroFab的过敏反应可能是严重的和危及生命的.
- 像ANAVIP这样的替代抗毒剂可能会被耐受于对CroFab.反应的患者.
- 管理需要迅速干预,并在多学科环境中考虑替代治疗方法.
相关概念视频
01:30Hypersensitivities
474
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
474
00:42Cross-reactivity
30.9K
Overview
30.9K
02:06Allergic Reactions
27.2K
Overview
27.2K
01:27Allergic Drug Reactions
800
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
800
01:10Antibody Structure
58.7K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
58.7K
01:51Vaccinations
43.3K
Overview
43.3K