METS-IR与女性不孕症之间的关联:NHANES 2013-2018年的横截面研究
Haiyan Li1, Hongxia Tan2, Zhenbo OuYang2
1Department of Reproductive Medicine Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Frontiers in nutrition
|March 17, 2025
概括
胰岛素抵抗的高代谢得分 (METS-IR) 与女性不孕症风险的增加有关. 这一发现表明,METS-IR可以作为评估女性不孕症的有价值指标.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢健康 代谢健康
- 公共卫生 营养 公共卫生 营养
背景情况:
- 肥胖和代谢综合征与女性不孕症和胰岛素抵抗 (IR) 有关.
- 胰岛素抵抗的代谢评分 (METS-IR) 是测量IR的新型指数.
- METS-IR对女性不孕症风险的预测价值尚未得到充分证实.
研究的目的:
- 调查胰岛素抵抗代谢得分 (METS-IR) 与女性不孕症风险之间的关联.
- 探索METS-IR作为女性不孕不育风险的潜在非胰岛素生物标志物.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2013-2018) 进行的横截面研究.
- 使用多变量逻辑回归,受限立方线 (RCS) 和值效应分析.
- 分析的重点是METS-IR水平与生育年龄女性自我报告的不孕症之间的关系.
主要成果:
- 较高的METS-IR受试者中,更高的比例报告了不孕症.
- METS-IR与女性不孕症的风险增加有显著关联 (OR=1.02,95% CI:1.01-1.04).
- RCS和值分析表明线性相关性,不孕不育风险显著增加,超过METS-IR的32.94.
结论:
- 升高的METS-IR水平与美国生育年龄女性的不孕症有关.
- METS-IR可以作为评估女性不孕症风险的有用,非侵入性指标.
- 进一步的研究是有必要的,以了解潜在的机制.
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