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配备自发泡生成的活性微针贴片,用于加强类风湿性关节炎治疗

Ting Liu¹, Jintao Fu², Ziyang Zheng³

¹School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

|March 17, 2025

概括

新型溶解微针 (MNs) 使用内置的化学反应来实现更快,更深的药物输送. 这种活性微针技术显著提高了诸如类风湿性关节炎等疾病的治疗疗效.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
纳米技术纳米技术

背景情况:

溶解微针 (MNs) 提供无痛的通过皮肤递送药物.
由于药物释放缓慢,常规MNs中的被动扩散限制了治疗疗效.

研究的目的:

开发一种新的可降解活性微针 (MN) 平台,用于增强皮内药物输送.
利用MN内部的化学反应来推动更深,更快的有效载荷传递.

主要方法:

开发了含有二碳酸和酸的活性MN.
研究了二氧化碳泡的形成,以便在与组织液接触时增强有效载荷的驱逐.
评估了活性MNs的机械特性,药物释放动力学和皮肤透.

主要成果:

活跃的MN表现出优越的机械性能和快速脱落.
与被动MNs相比,皮肤模型中的药物透和分布得到了增强.
活跃的MN在类风湿性关节炎的小鼠模型中显示出显著改善的治疗疗效.

结论:

开发的活跃MN提供了一个有效的自主动态微针配送系统.
这项技术可以提高药物治疗效率,并具有各种应用的潜力.
该平台易于准备和使用,用于通过皮肤递送药物.

关键词:

活跃的微针是微针.产生的泡是产生泡的.快速分离的快速分离类风湿性关节炎类风湿性关节炎通过皮肤传递药物.

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