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验证动态F-FDG长轴视野PET/CT研究中的图像衍生输入函数

Charlotte L C Smith^1,2, Gerben J C Zwezerijnen^1,2, Marijke E den Hollander¹

¹Department of Radiology and Nuclear Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Frontiers in nuclear medicine

|March 17, 2025

概括

来自大动脉的图像导入函数 (IDIF) 是动态18F-FDG PET成像的可靠,非侵入性替代血液采样. 这种方法简化了协议,并提高了LAFOV PET/CT系统上的患者安全.

科学领域:

医疗成像医学成像
核医学就是核医学.
放射化学放射化学是指辐射化学.

背景情况:

动态PET成像需要一个输入函数,传统上通过血液采样获得.
来自大动脉或左心室的图像导入函数 (IDIF) 提供了非侵入性的替代方案,特别是在长轴视野 (LAFOV) PET/CT系统中.
拉福PET/CT可实现全身动态18F-FDG成像,使得非侵入性输入功能评估至关重要.

研究的目的:

验证来自上升大动脉 (AA),大动脉,下降大动脉 (DA) 和左心室 (LV) 的未经纠正的IDIF.
为了将这些IDIF与接受LAFOV PET/CT的患者的静脉全血样本进行比较.
在动态18F-FDG PET成像中评估IDIFs随时间的准确性和偏差.

主要方法:

11名瘤学患者在LAFOV PET/CT系统上进行了长达70分钟的18F-FDG动态PET/CT扫描.
在注射后的确定的时间点 (5-60分钟) 手动采集了七个静脉血液样本.
IDIFs来自AA,大动脉门,DA和LV,并与血液样本进行偏差评估.

主要成果:

随着时间的推移,IDIF的准确性得到了改善,注射后25分钟的中位数百分比偏差为<10%.
在注射后60分钟,大动脉门显示出最低的偏差 (-1.1%),其次是AA (2.5%),DA (5.1%),LV (7.4%).
来自大动脉的IDIF显示出高精度,与静脉血液样本相比显示出可靠性.

结论:

大动脉衍生IDIF是一种可靠的,非侵入性的替代手动血液采样,用于LAFOV PET/CT系统上的动态18F-FDG PET.
使用IDIF简化了协议,减少了变化,并最大限度地减少了辐射暴露.
这种非侵入性方法提高了患者的安全性,并简化了PET成像工作流程.

关键词:

在18F-FDG中.IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF IDIF 拉夫夫皮特 (LAFOV PET) 是一个非常有价值的品种.动态PET成像技术非侵入性的量化量化.

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