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Updated: Jul 27, 2026

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms
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拉尼祖马布结合VEGF的溶液相动力学使用固相表面等离子体共振

John G Quinn1

  • 1Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States.

Analytical chemistry
|March 17, 2025
PubMed
概括

开发像Ranibizumab这样有效的抗VEGF疗法需要精确的动态结合测量. 这项研究引入了一种新的测定方法,以准确确定药物开发中至关重要的高 afinity 相互作用.

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相关概念视频

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...