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Updated: May 22, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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激活的T细胞通过巨细胞再教育来破坏瘤免疫抑制

Rosa Trotta1, Silvia Rivis2, Shikang Zhao1

  • 1KU Leuven-VIB, Belgium.

Cancer discovery
|March 17, 2025
PubMed
概括

在瘤巨细胞中,T细胞激活抑制了造血性前列腺素-D2合成酶 (HPGDS),这通常促进癌症生长. 向HPGDS可以增强抗瘤免疫力,并改善免疫治疗反应.

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