在跨性别成年人中,性别确认激素治疗和抑郁症状
Sari L Reisner1,2,3,4,5, David R Pletta1, Alex S Keuroghlian5,6
1Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor.
JAMA network open
|March 17, 2025
概括
性别确认激素疗法 (GAHT) 在跨性别,非二进制和性别多样性 (TGD) 成人中显著减少了中度至重度的抑郁症状. 这项研究支持性别确认的初级保健模型,以改善TGD心理健康结果.
科学领域:
- 心理健康研究 心理健康研究
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 跨性别,非二进制和性别多样性 (TGD) 的成年人经历了高抑郁率.
- 性别肯定激素疗法 (GAHT) 显示出改善心理健康的前景,但之前的美国研究缺乏长期数据和多样化的样本.
研究的目的:
- 评估GAHT在初级保健中对各种TGD成年人中中度至重度抑郁症状的有效性.
- 评估GAHT作为联邦资格社区卫生中心的干预措施.
主要方法:
- 在LEGACY观察队列研究中,从2016年到2019年,追踪了3592名TGD患者.
- 从电子健康记录确定GAHT暴露;使用PHQ-9/PHQ-2测量抑郁症状.
- 通用估计方程 (GEE) 纵向建模了GAHT和抑郁症状之间的关联,并对共变量进行了调整.
主要成果:
- 该研究包括多样化的TGD人口 (平均年龄28岁,多种种族/种族,18.9%非二进制).
- 在基线时,84.5%接受了GAHT,15.3%报告中度至重度的抑郁症状.
- 处方GAHT的患者患中度至重度抑郁症状的风险显著降低 (aRR,0.85;95% CI,0.75-0.98).
结论:
- 在多样化的TGD成年人群中,GAHT与中度至重度抑郁症状的降低率有关.
- 调查结果强调了性别确认初级保健在支持TGD心理健康方面的关键作用.
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