对甲状腺癌患者临床病理特征和预后变化的评估
Özlem Doğan1, Melin Aydan Ahmed2, Ömer Burak Ekinci3
1Department of Endocrinology, Health Sciences University, Haseki Training and Research Hospital, Istanbul 34265, Turkey.
Journal of clinical medicine
|March 17, 2025
概括
这项研究使用SEER数据分析了20多年的甲状腺癌趋势. 它发现老年,男性和乳头甲状腺癌病例的增加,随着年龄,性别和阶段影响预后.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 甲状腺癌的发病率和特征在过去二十年里有所发展.
- 了解这些变化对于有效的患者管理和公共卫生战略至关重要.
研究的目的:
- 评估甲状腺癌临床病理特征的时间变化.
- 评估预后的变化,并在20年内确定关键预后因素.
主要方法:
- 使用的监测,流行病学和最终结果 (SEER) 数据库 (SEER-12注册,1992-2021年).
- 分析了2001年至2020年期间诊断出恶性甲状腺癌的94,892名患者的数据.
- 将两个队列进行比较:2001-2010年 (第一队列) 和2011-2020年 (第二队列).
主要成果:
- 与第一队 (p < 0.001) 相比,第二队的60岁以上 (+4.2%),男性 (+2.1%),乳头甲状腺癌 (+5.3%) 和区域性疾病 (+3.7%) 的患者显著增加.
- 在第2组中观察到改善生存率的非显著趋势 (8%的改善,p = 0.057).
- 确定年龄,性别,起源,组织病理学亚型和诊断时的阶段作为显著的预后因素. 乳头瘤+FV亚型的预后最好 (HR:0.78),而形瘤/肉瘤的预后最差 (HR:9.61).
结论:
- 在2001-2010年和2011-2020年期间,在甲状腺癌患者中观察到显著的人口和病理变化.
- 年龄,性别,起源,组织病理学亚型和诊断阶段是甲状腺癌的关键预后指标.
- 改善生存率的趋势表明,不断发展的管理策略可能会带来潜在的好处,这需要进一步调查.
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