在活性甲状腺眼病患者的抗炎疗法后,眼外肌肉和眼内压力的变化之间的相关性
Yusuke Haruna1, Mizuki Tagami1, Mami Tomita1
1Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka-shi 5450051, Osaka-fu, Japan.
Journal of clinical medicine
|March 17, 2025
概括
用皮质类固醇治疗甲状腺眼病降低了眼内压力 (IOP) 和眼外肌肉大小. 下方直肠肌肉是指下方直肠肌肉的下部直肠肌肉.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 甲状腺眼病 (TED) 可以导致明显的眼部并发症,包括眼外肌肉 (EOM) 和眼内压力 (IOP) 的变化.
- 了解TED中EOM形态和IOP之间的关系对于有效管理至关重要.
- 皮质类固醇治疗是活跃TED的常见治疗方法.
研究的目的:
- 调查TED患者在皮质类固醇治疗前和后EOM和IOP的功能和形态变化之间的相关性.
- 为了确定与TED治疗期间IOP变化相关的特定EOM参数.
主要方法:
- 对TED患者接受皮质类固醇治疗的回顾性多中心图表审查.
- 磁共振成像 (MRI) 用于测量EOM截面积 (CSA) 和信号强度比 (SIR).
- 在IOP和EOM参数 (CSA,SIR) 在治疗前和后的变化之间的相关性分析.
主要成果:
- 在接受皮质类固醇治疗后,内血压显著下降 (18 ± 3.4 mmHg至 15.5 ± 2.9 mmHg,p < 0.01).
- EOM和轨道脂肪组织CSA和SIR在治疗后显著下降 (p <0.05).
- 下直肠肌 (IRM) 的CSA变化率与IOP变化率有显著的正相关性 (R2 = 0.24,p < 0.05).
结论:
- 抗炎治疗单独可以降低TED患者的内压.
- 在TED中,IRM尺寸的缩小是与IOP降低相关的关键因素.
- 这些发现突出了EOM变化对TED中的IOP的影响,并提出了潜在的治疗目标.
相关概念视频
Open Angle Glaucoma: Treatment
378
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
378
Accessory Structures of the Eye
1.4K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.4K
Glaucoma: Overview
488
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
488
Angle Closure Glaucoma: Treatment
420
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
420
Muscles of the Eye
1.0K
The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
1.0K


