动脉样硬化和慢性牙牙周炎:系统性审查和元分析
María León-López1, Daniel Cabanillas-Balsera1, Jenifer Martín-González1
1Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain.
Journal of clinical medicine
|March 17, 2025
概括
动脉样硬化患者患慢性牙周炎 (CAP) 的患病率几乎是慢性牙周炎 (CAP) 的三倍. 这突显了口腔炎和心血管健康之间的联系,表明综合护理至关重要.
科学领域:
- 心血管健康 心血管健康
- 口腔医学是指口腔医学.
- 系统性炎症 系统性炎症
背景情况:
- 动脉样硬化是一种慢性动脉疾病,涉及斑块形成和轻度炎症.
- 慢性牙周炎 (CAP) 是一种与全身炎症相关的持续性口腔炎症状况.
- 动脉样硬化和CAP之间的潜在关联需要调查,因为它们有共同的炎症途径.
研究的目的:
- 系统地审查和元分析CAP在患有动脉样硬化和没有动脉样硬化的成年患者中的患病率.
- 为了回答PICO的问题:动脉样硬化的存在是否会影响成人中CAP的患病率?
主要方法:
- 按照PRISMA指南进行的系统审查和元分析,注册在PROSPERO (651359) 中.
- 搜索了PubMed-MEDLINE,Embase和Scielo的研究,比较了动脉样硬化患者与对照者的CAP患病率.
- 提取数据,进行随机效应元分析,评估偏差风险 (纽卡斯尔-太华尺度),评估证据质量 (GRADE).
主要成果:
- 五项研究符合从102个获取的文章中包含的标准.
- 分析显示,在动脉样硬化患者中,CAP的患病率显著更高 (OR = 2.94;95% CI = 1.83-4.74;p < 0.01).
- 发现了偏见的中等风险和证据的低确定性.
结论:
- 患有动脉样硬化的人患有CAP的可能性几乎是3倍.
- 研究结果支持口腔炎影响心血管健康的假设,倡导综合口腔和全身医疗保健.
- 临床医生应考虑在动脉样硬化患者中使用CAP,并查动脉样硬化患者的CAP.
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