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Updated: May 22, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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从封闭到开放:膜结合的细胞染色体P450 3A4的三个动态状态

Vera A Spanke1, Valentin J Egger-Hoerschinger1, Veronika Ruzsanyi2

  • 1Department of Theoretical Chemistry, Universität Innsbruck, Innsbruck, Austria.

Journal of computer-aided molecular design
|March 17, 2025
PubMed
概括

分子动力学模拟显示了P450 3A4 (CYP3A4) 细胞染色体的三个不同的状态,突出了膜环境在药物代谢和酶动力学中的关键作用.

关键词:
一致性 形状 形状细胞染色体P450 3A4 4A4 细胞染色体P450 3A4 细胞染色体P450 3A4膜膜是一种膜.分子动力学模拟的模拟.道 道 道

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