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Angelico Mendy¹, Tesfaye B Mersha²

¹Division of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, 160 Panzeca Way, Room 335, Cincinnati, OH, 45267, USA. angelico.mendy@uc.edu.

|March 17, 2025

概括

表观遗传年龄加速 (EAA) 预测死亡率,而灰色EAA是整体和心血管死亡的强有力的预测因素. 然而,预测准确性因种族/族群而异,特别是在西班牙裔参与者中显示有效性降低.

科学领域:

表观遗传学和衰老研究.
衰老的生物标志物.
死亡率预测研究.

背景情况:

表观遗传钟为生物衰老提供了新的见解.
表观遗传衰老加速 (EAA) 是死亡率的潜在预测因素.
存在不同的表观遗传时钟,每个都有独特的特性.

研究的目的:

评估各种表观遗传钟对全因,心血管和癌症死亡率的预测能力.
调查老龄化速度是否影响死亡率预测.
检查EAA在种族/种族群体之间对死亡率预测的潜在差异.

主要方法:

利用了1999-2002年国家健康和营养检查调查中的2105名参与者 (年龄≥50岁) 的数据.
使用九个不同的表观遗传钟计算EAA,对时间年龄进行回归.
评估了EAA,衰老速度和死亡结果之间的关联,并对共变量进行调整,平均随访时间为17.5年.

主要成果:

格林EAA显著预测了整体死亡率 (P < 0.0001) 和心血管死亡率 (P < 0.0001).
汉纳姆,霍瓦斯和格里姆EAAs预测了癌症死亡率.
霍尔瓦斯,汉纳姆和格林EAAs的死亡率预测因种族/种族而异,显示西班牙裔参与者的预测能力有所降低.

结论:

一些表观遗传时钟,包括Grim,Hannum和Horvath,有效地预测了美国代表样本中的死亡率.
脑衰老和衰老的速度是所有原因,心血管和癌症死亡率的重要预测因素.
某些表观遗传钟对死亡率的预测效用因种族和族群而异,突出了对这些差异的进一步研究的需要.

关键词:

癌症癌症癌症癌症心血管疾病是什么心血管疾病表观遗传年龄加速基因表观时钟是什么?死亡率死亡率死亡率

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