评估老年人肠道微生物群的组成:与身体活动和健康衰老的联系
Catarina Ramos1, Daniele Magistro2, Gemma E Walton3
1Department of Sport Science, Sport, Health and Performance Enhancement (SHAPE) Research Centre, Nottingham Trent University, Nottingham, UK. catarina.fernandesramos@ntu.ac.uk.
GeroScience
|March 17, 2025
概括
身体活动 (PA) 可以改善老年人的肠道微生物群 (GM). 满足PA建议会增加有益细菌并减少有害细菌,可能扭转与年龄相关的肠道不平衡并促进健康的衰老.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 肠道微生物群 (GM) 的组成和功能在整个生命周期中发生变化.
- 衰老与转向不那么健康的转基因转变有关,可能导致失能.
- 应对与年龄相关的失生症的策略对于健康的衰老至关重要.
研究的目的:
- 为了比较不同体力活动 (PA) 水平的老年人肠道微生物组成.
- 评估AP水平与老年人健康衰老指标之间的关联.
主要方法:
- 101名参与者 (65-85岁) 进行了人体测量和6分钟步行测试.
- 参与者佩戴加速度计7天,以量化身体活动.
- 用16S rRNA测序分析便样本以检测肠道微生物群的组成.
主要成果:
- 符合世卫组织/英国PA建议的老年人表现出更多的有益细菌 (例如,乳酸菌,F. prausnitzii,Roseburia intestinalis).
- 这些人也有较低的疾病相关细菌 (例如,D. piger,Enterobacterales).
- 在那些符合和不符合PA建议的人之间观察到转基因成分的显著差异.
结论:
- 身体活动可以积极调节老年人肠道微生物群的组成.
- 增殖器具有部分逆转与年龄相关的肠道失调的潜力.
- 保持足够的体力活动与更健康的肠道微生物组有关,并可能促进健康的衰老.
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