解读腹部疼痛在便秘占主导地位的刺激性肠综合征和功能性便秘:机制和管理
Jingyuan Luo1,2, Qianqian Xu1,3, Shujun Xu2
1Vincent V.C. Woo Chinese Medicine Clinical Research Institute, School of Chinese Medicine, Hong Kong Baptist University, 3/F, Jockey Club School of Chinese Medicine Building, 7 Baptist University Road, Kowloon Tong, Hong Kong, SAR, China.
Current gastroenterology reports
|March 17, 2025
概括
在便秘占主导地位的刺激性肠综合征 (IBS-C) 和功能性便秘 (FC) 中,腹痛是复杂的. 研究强调IBS-C的内脏过敏和肠-大脑轴问题,FC疼痛与膨胀有关,但向治疗仍然有限.
科学领域:
- 胃肠病学 胃肠病学
- 神经胃肠病学 神经胃肠病学
- 疼痛医学 医学 疼痛医学
背景情况:
- 在便秘占主导地位的刺激性肠综合征 (IBS-C) 和功能性便秘 (FC) 中,腹痛是一个重大的临床挑战.
- 病理生理机制尚未完全理解,针对疼痛的治疗方法有限.
研究的目的:
- 批判性地审查有关IBS-C和FC的疼痛机制的证据.
- 探索当前的管理策略,其局限性,以及未来的研究方向.
主要方法:
- 文献综述侧重于IBS-C和FC疼痛机制.
- 评估现有和新兴的治疗策略.
主要成果:
- 内脏过敏,血清激素失调和肠-大脑轴功能障碍与IBS-C疼痛有关.
- FC疼痛可能主要与结肠膨胀和运动性问题有关.
- 目前的管理策略提供了症状缓解,但由于异质的病理生理学,缺乏普遍的疗效.
结论:
- 开发针对IBS-C和FC腹痛的向疗法需要更深入地了解不同的疼痛机制.
- 未来的研究应该优先考虑生物标志物识别,精细的诊断和先进的技术,如多omics和神经成像.
相关概念视频
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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