使用复发分区分析对因局部复发的口腔状细胞癌而接受救援手术的患者进行预后预测
Toshihiko Sakai1, Go Omura2, Kohtaro Eguchi2
1Department of Head and Neck Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan. tsakai8312@gmail.com.
International journal of clinical oncology
|March 17, 2025
概括
这项研究确定了在接受救援手术的复发性口腔癌患者中预测结果的关键因素. 一个新的风险分类有助于量身定制治疗策略,以便更好地选择患者.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 癌症预后 癌症预后
背景情况:
- 局部复发的口腔状细胞癌 (LR-OCSCC) 尽管经过救援手术,预后不佳.
- 识别不良预后因素对于改善患者的治疗结果至关重要.
研究的目的:
- 为了确定LR-OCSCC患者的不良预后因素.
- 开发使用递归分区分析 (RPA) 的预后分类.
主要方法:
- 对75名为LR-OCSCC进行救援手术的患者进行了回顾性审查.
- 考克斯比例危险回归模型用于预后因素分析.
- 基于生存结果的患者分类的RPA.
主要成果:
- 三年总生存率 (OS) 为53.4%;局部区域复发率为32.7%.
- 不良因素包括同时区域复发,先前的部放射治疗和12个月内复发.
- RPA将患者分为低风险 (73.3%的3年OS),中等风险 (53.3%) 和高风险 (24.4%) 组.
结论:
- 为LR-OCSCC救援手术开发了一种新的预后分类.
- 这种分类有助于制定治疗策略和为救援手术选择患者.
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