个性化基于算法的间歇性缺氧改善了COVID-19感染后长期后果患者的生活质量
Josephine Schultz Kapel1, Rasmus Stokholm1, Brian Elmengaard1
1SANA Medical Systems, 8240 Risskov, Denmark.
Journal of clinical medicine
|March 17, 2025
概括
个性化间歇性缺氧-过氧条件 (IHHC) 显著改善了长期COVID患者的生活质量和减少疼痛. 这些对COVID-19后症状的积极影响持续了至少六个月.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 神经学 神经学
- 康复医学 康复医学 康复医学
背景情况:
- 后COVID-19条件 (PCC),或长期COVID,影响全球数百万,造成显著的生活质量损害.
- 目前对PCC的治疗选择有限,这凸显了对有效治疗的需要.
- 这项研究研究了一种用于管理持续长期COVID症状的新方法.
研究的目的:
- 评估PCC患者个性化,基于算法的间歇性缺氧-过氧条件 (IHHC) 的长期疗效.
- 评估IHHC对长期COVID患者生活质量和疼痛水平的影响.
- 为了确定IHHC治疗后治疗效果的持续时间.
主要方法:
- 一项开放的队列研究,涉及199名PCC患者 (11-87岁) 患有中度至重度疲劳.
- 患者接受了个性化,基于算法的IHHC治疗,包括低氧 (9-13%O2) 和高氧 (34-36%O2) 的周期.
- 测量结果包括疼痛 (NRS) 和生活质量 (SF-36) 评分在6周和6个月的随访后的变化.
主要成果:
- 在6周 (Δ102分) 观察到SF-36生活质量得分的显著改善,并在6个月 (Δ106分) 持续 (p < 0.001).
- 在两个随访点,疼痛减轻程度在28-32%之间,超过了临床相关性值.
- 患者报告的健康过渡得分表明,治疗后的整体健康状况有所改善.
结论:
- 个性化,基于算法的IHHC有效地缓解疼痛,并提高COVID-19长期后果患者的生活质量.
- 对于COVID-19后的病情,IHHC的治疗效益持续了长达六个月.
- 建议进行进一步的研究,以阐明IHHC在PCC患者中有效性的潜在机制.
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