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Updated: May 21, 2025

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

晚期加多利尼增强量化和昏迷在过敏心肌病的预后影响

Christopher Mann¹, Theresa M Dachs², Diana Gharib¹

¹Division of Cardiology, Department of Medicine II, Medical University of Vienna, 1090 Vienna, Austria.

Journal of clinical medicine

|March 17, 2025

概括

过度缩性心肌病 (HCM) 的突然心脏死亡风险更好地预测到心脏MRI上的昏迷史或甚至小量的晚期加多增强 (LGE),而不是ESC HCM风险评分.

科学领域:

心脏病学心脏病学
心血管成像 - 心血管成像
遗传学是一个遗传学.

背景情况:

在高性心肌病 (HCM) 中突然心脏死亡 (SCD) 的风险分层是临床上具有挑战性的.
晚期加多增强 (LGE) 在心脏MRI上表明心肌纤维化,并且与HCM的不良结果有关.
在HCM中,LGE临床意义的确切门是有争议的.

研究的目的:

调查小量的LGE (≥5%) 和昏迷与HCM患者不良结果的关联.
与ESC HCM风险评分相比,评估LGE和昏迷的预测值.

主要方法:

从2018年5月到2023年6月,预计将230名HCM患者在第三级转诊中心注册.
主要终点:综合新发的腹腔动心,适当的ICD治疗和全因死亡率.
随访时间中位数为3.2年;分析LGE程度和昏迷史.

主要成果:

29名患者 (13%) 达到复合终点.
LGE > 5% (相应的比例) HR 6.16) 和昏迷史 (调整) 的情况. HR 3.40) 独立地与不良结果相关.
ESC HCM 风险评分没有预测初级终点.

结论:

在心脏MRI上,昏迷史和LGE≥5%是HCM不良结果的显著独立预测因素.
这些发现表明,LGE范围和昏迷对于HCM的风险分层至关重要.
这些因素无论左心室外流通道阻塞状态如何,都很重要.

关键词:

过度缩性心肌病变性心脏病.磁共振是一种磁共振.心肌纤维化是心肌纤维化的一种.风险分层的分层是风险分层.综合症综合症是什么腹腔心律不整腹腔心律不整

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