美国明尼苏达州的克罗诺细菌监测,2002-2024年
Joshua Rounds1, Jennifer L Dale1, Annastasia Gross1
1Minnesota Department of Health, St. Paul, Minnesota, USA.
Foodborne pathogens and disease
|March 17, 2025
概括
在明尼苏达州,婴儿感染Cronobacter sakazakii的病例是必须报告的. 2002-2024年间的监测数据确定了23例婴儿病例,其中序列类型4占主导地位,并与婴儿配方奶粉污染有关.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生监督 公共卫生监督
背景情况:
- 克罗诺巴克特 (Cronobacter sakazakii) 是一种机会性病原体,在新生儿和婴儿中引起严重感染.
- 自2003年以来,明尼苏达州一直在婴儿中监测C. sakazakii,国家通知将于2024年实施.
- 这项研究提供了超过二十年的监控数据,以告知其他司法管辖区.
研究的目的:
- 总结和分析明尼苏达州婴儿20年可报告的C. sakazakii监测数据.
- 描述侵入性和非侵入性C. sakazakii病例并确定常见的序列类型.
- 调查C. sakazakii病例与婴儿配方奶粉 (PIF) 之间的潜在联系.
主要方法:
- 在2002年至2024年期间报告的23例C. sakazakii婴儿病例的回顾性分析.
- 使用 MALDI-TOF 或常规生化方法确认病例.
- 临床分离物和PIF样本的全基因组测序 (WGS) 用于相关性评估.
主要成果:
- 总共有23例婴儿病例 (8例侵入性,15例非侵入性) 被确定.
- 侵袭性病例比非侵袭性病例要年轻得多.
- 序列类型4 (ST4) 主导,占所有病例的65%,占侵袭性婴儿病例的88%.
- 在开放和未开放的PIF样本中检测到C. sakazakii ST 4.
- WGS证实与已知的疫情没有关联,这表明PIF准备期间的家庭污染.
结论:
- 婴儿配方奶粉 (PIF) 是婴儿中C. sakazakii感染的可能来源.
- 家庭准备实践和护理人员教育对于预防C. sakazakii感染至关重要.
- 长期监测数据对于了解和控制这种病原体是有价值的.
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