探索肠道微生物群在抗生素耐药性和预防中的作用
Devyani S Dongre1, Ujjayni B Saha1, Sunil D Saroj1
1Symbiosis School of Biological Sciences (SSBS), Symbiosis International (Deemed University) (SIU), Lavale, Pune, Maharashtra, India.
抗菌素耐药性 (AMR) 是一个主要的公共卫生威胁. 探索肠道微生物组的探索
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 和多药耐药性 (MDR) 细菌的增加构成了全球重大公共卫生挑战.
- 病原体和宿主微生物群之间的相互作用对于确定疾病结果至关重要.
- 人们越来越认识到肠道微生物组是抗生素耐药性基因 (ARG) 的储存库,有助于整体抗菌组.
研究的目的:
- 审查肠道微生物群在抗菌素耐药性背景下的作用.
- 探索肠道微生物群作为新型抗菌战略的目标.
- 讨论抗生素诱导的肠道失生症及其与AMR的联系的含义.
主要方法:
- 这是一篇综述性文章,综合了有关肠道微生物组和AMR的现有研究.
- 关于抗生素对肠道微生物群组成的影响的文献分析.
- 检查肠道失调有助于AMR的机制.
主要成果:
- 抗生素破坏了本地肠道微生物群,促进了耐药细菌和机会性感染的扩散.
- 可能由食物和环境中的亚治疗性抗生素暴露引起的肠道失生症与AMR有关.
- MDR细菌可以在肠道微生物群中殖民和持续存在,加剧AMR挑战.
结论:
- 了解微生物多样性及其在病原体适应AMR中的作用至关重要.
- 预防或治疗肠道失生症的策略,如便微生物种移植,益生菌,益生菌,菌体治疗和抗菌药物管理,是必不可少的.
- 针对微生物组与病原体相互作用,为开发新型抗微生物药物来对抗AMR提供了一个有希望的途径.
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