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第二种原发性癌症和前列腺癌的荷尔蒙疗法:一个嵌套的病例对照研究
Lucie-Marie Scailteux1,2, Julien Bezin3, Marion Gundelwein2
1Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
新的前列腺癌药物恩扎胺 (ENZ) 和阿比拉 (ABI) 可能会增加患第二次原发性癌症 (SPC) 的风险. 最近的暴露表明与SPC的相关性更高,但需要更多的长期数据.
科学领域:
- 在瘤学瘤学.
- 药物监督 药物监督 药物监督
- 癌症流行病学 癌症流行病学
背景情况:
- 雄激素受体通路抑制剂 (ARPI) 用于治疗前列腺癌.
- 临床前和临床研究并没有完全排除ARPI,特别是恩扎胺 (ENZ) 的第二次原发性癌症 (SCP) 的潜在风险.
研究的目的:
- 调查ARPI (阿比拉 [ABI]和恩扎胺 [ENZ]) 与患第二次原发性癌症 (SPC) 的风险之间的关联.
主要方法:
- 使用法国健康声明数据库 (2013-2020年) 进行了一项病例控制研究.
- 包括开始安卓素缺乏治疗的患者,病例定义为12个月的潜伏期后被诊断出SPC的患者.
- 选择了匹配的对照组,并分析了对ABI和ENZ的暴露模式,时隔一年.
主要成果:
- 该研究包括147,092名患者,其中7,928例SPC.
- SPC主要影响消化器官,泌尿道或肺部.
- 最近短期接触ENZ与SPC相关 (OR 1.7).
- 最近暴露于ABI一年或更长时间也与SPC相关 (OR 1.8-2.3).
结论:
- 第二种原发性癌症 (SPC) 病例主要在最近暴露的患者中观察到,这表明潜在的检测偏差.
- 长期暴露于ARPI的患者数量有限,因此无法就长期风险得出明确的结论.
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