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血红蛋白糖化指数与缺血性中风死亡率之间的非线性关联患者:来自MIMIC-IV数据库的见解

Xuhang Huang¹, Lejun Huang¹, Haoran Tao¹

¹Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou Key Laboratory for Metabolic Diseases, Guangzhou 510120, China.

Diabetes research and clinical practice

|March 17, 2025

概括

较低的血红蛋白糖化指数 (HGI) 与危急缺血性中风患者的结果更差有关. 较高的HGI可能会提供短期的保护,但会增加长期的死亡风险,白细胞数量起着调解作用.

科学领域:

生物化学生物化学
临床医学临床医学
神经学神经学

背景情况:

血红蛋白糖化指数 (HGI) 是血糖控制的标志物,与各种疾病的不良结果有关.
在危急性缺血性中风患者中,HGI的预后价值仍未得到充分研究.

研究的目的:

研究HGI与临界缺血性中风患者的预后之间的关联.
探索白细胞 (WBC) 在这种关系中的潜在调解作用.

主要方法:

利用医学信息中心的密集护理IV (MIMIC-IV) 数据库对2,332名患者的队列的数据.
采用卡普兰-梅尔分析,多变量回归和限制立方线 (RCS) 来评估HGI结果关联.
构建调解模型来评估WBC计数的作用.

主要成果:

医院住院死亡率在HGI组之间有显著差异 (P < 0.001).
较低的HGI与死亡风险增加有关.
在HGI和短期死亡率之间观察到一个L形的关联,而长期死亡率发现了一个反向的J形关系. 这些协会通过WBC计数进行调解.

结论:

较低的HGI始终与临界缺血性中风的较差结果有关.
较高的HGI可能在短期内有保护作用,但会带来长期的死亡风险.
白血细胞计数显著调解了HGI与该患者群体的结果之间的关系.

关键词:

血红蛋白糖化指数是血红蛋白糖化指数.缺血性中风是因为缺血性中风.这是一个MIMIC-IV数据库.调解分析调解分析追溯性队列研究追溯性队列研究

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