在COVID-19感染后的扩散张力成像:系统性审查
Breanna K Nelson1, Lea N Farah1, Sidney A Saint1
1University of British Columbia, Department of Psychiatry, 2255 Wesbrook Mall Vancouver, BC Canada; British Columbia Children's Hospital Research Institute, 938 West 28th Ave Vancouver, BC Canada; British Columbia Mental Health and Substance Use Services Research Institute, 938 West 28th Ave Vancouver, BC Canada.
NeuroImage
|March 17, 2025
概括
慢性COVID-19的大脑变化尚不清楚. 扩散MRI (dMRI) 研究显示出混合的结果,严重程度和时间影响了感染后白质完整性差异.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 对COVID-19对大脑结构的慢性神经学影响的理解有限.
- 在先进的神经成像,特别是扩散MRI (dMRI) 中,关于COVID-19后白质完整性的不一致的发现.
研究的目的:
- 系统地审查先进的神经成像文献.
- 专注于COVID-19疾病急性阶段后的dMRI异常.
主要方法:
- 综合文献搜索 (PubMed,Embase,Scopus) 更新时间:2024年9月.
- 纳入标准:定量dMRI比较,COVID-19与对照,MRI>感染后6周.
- 排除标准:特定症状子组,病例报告,死后研究.
主要成果:
- 11项研究符合纳入标准;大多数涉及住院患者,感染后2-6个月接受MRI.
- 大多数人报告说,在COVID-19后的队列中,分数异构性较低,平均扩散性较高.
- 结果各不相同;严重的疾病和较短的随访时间与较大的dMRI差异相关.
结论:
- 在dMRI发现中的异质性可能是由于COVID-19的严重程度和MRI的时间.
- 未来的研究应该探索SARS-CoV-2变种对结构性大脑差异的影响.
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