白质微观结构与青春期,中期和晚期的脑,身体和遗传属性联系在一起
Max Korbmacher1, Mario Tranfa2, Giuseppe Pontillo3
1Neuro-SysMed Center of Excellence for Clinical Research in Neurological Diseases, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Mohn Medical Imaging and Visualization Centre (MMIV),Department of Radiology, Haukeland University Hospital, Bergen, Norway; Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway.
NeuroImage
|March 17, 2025
概括
不同的扩散MRI模型显示了与大脑健康现象型 (如年龄和性别) 的不同关联. 白质微观结构在整个生命周期中与基因型和表型有不同的关系.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 先进的扩散磁共振成像 (dMRI) 模型在体内评估大脑白质组织.
- 现有的dMRI模型具有重叠的特征,在神经科学中具有潜在的互补价值.
- 关于dMRI指标与临床相关的表型/基因型之间的关系仍在争论中.
研究的目的:
- 调查dMRI指标与WM相关的表型 (性别,年龄,脉压,BMI,大脑不对称) 之间的关联.
- 检查两个大型队列 (英国生物银行和ABCD研究) 中与遗传标记的关系.
- 确定不同dMRI方法在多大程度上解释了这些表型.
主要方法:
- 从多种dMRI方法中利用了基于导管和整个WM骨架的参数.
- 分析了来自英国生物库 (n=52,140) 和ABCD研究 (n=5,844) 的数据.
- 与表型相关的dMRI指标包括年龄,性别,BMI,脉冲压和遗传标记.
主要成果:
- 没有单一的dMRI方法解释了所有表型,但方法显示了类似的整体解释能力.
- 多隔间贝叶斯式dMRI显示与年龄的关联最强;dMRI和扩散张力成像是性别分类的最佳方法.
- 库尔托斯是BMI和双相情感障碍多基因分数的最有意义的迹象.
- 与表型和基因型的WM微观结构关联在整个生命周期中各不相同.
结论:
- 白质微观结构与临床相关的基因和基因型有差异性关联.
- 特定的dMRI参数提供了对年龄,性别,BMI和遗传倾向的见解.
- 这些发现突出了大脑结构,健康和遗传学在不同生命阶段之间的复杂相互作用.
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