替代剂可降低大多数肝硬化患者的发病率和死亡率
Elliot B Tapper1, Xi Chen1, Neehar D Parikh1
1Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan.
概括
丸激素替代疗法在患有肝硬化和阴性双胞胎症的男性中与降低死亡率和减少脱补偿事件有关. 这项研究表明,这组患者的临床结果有所改善.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 临床试验 临床试验
背景情况:
- 患有肝硬化的男性经常经历低丸激素水平,影响生活质量.
- 这种性质低的性质与萨尔科佩尼亚和贫血有关.
- 对这些患者用替代药物治疗的影响的临床数据有限.
研究的目的:
- 为了评估丸激素替代疗法的临床影响,在男性肝硬化和阴性腺缺陷症.
- 评估丸激素使用与死亡率,疾病脱补偿和骨折等结果之间的关联.
主要方法:
- 一个模拟的临床试验使用医疗保险数据 (2008-2020年) 对被诊断患有阴道腺缩和肝硬化的患者.
- 采用了一个"新用户"设计,用于平衡队列的治疗权重的逆概率.
- 利用治疗意图的方法来分析结果.
主要成果:
- 的使用与显著降低的死亡率有关 (sHR,0.92;95% CI,0.85-0.99).
- 观察到新的脱补偿事件的风险降低,特别是风和水出血.
- 没有发现肝细胞癌或骨折的风险增加;对肝脑病变的影响不那么明显.
结论:
- 替代疗法在老年男性患有肝硬化和阴性腺的患者中显示出改善的临床结果.
- 这些发现支持在这种特定患者群体中使用丸激素治疗.
- 进一步的研究可能会探索跨子组的治疗效果异质性.
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