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Updated: May 21, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

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通过全面描述共识TAD边界,BINDER实现了对等级TAD的准确识别

Yangyang Liu1, Bingqiang Liu2, Juntao Liu3

  • 1School of Mathematics and Statistics, Shandong University (Weihai), Weihai, 264209, China.

Genome research
|March 17, 2025
PubMed
概括

BINDER精确地识别了层次化的TAD边界,改进了现有的方法. 这种新的算法增强了对细胞分化过程中的表观遗传组织和基因调节的理解.

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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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Ladder diagrams are useful for evaluating equilibria involving metal-ligand complexes. The vertical scale of the ladder diagram represents the concentration of unreacted or free ligand, pL. The horizontal lines on the scale depict the log of stepwise formation constants for metal-ligand complexes and indicate the dominant species in all the regions.
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